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The Personal Genome Machine (PGM™) Sequencer is a benchtop PostLight™ semiconductor-based platform that performs a sequencing run in approximately two hours. With a small benchtop footprint and a weight of <?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" />65 lbs (~30kg), low cost sequencing reagents, and simple touchscreen user interface, the Personal Genome Machine (PGM™) Sequencer brings next generation sequencing to every lab. The PGM™ Sequencer requires a Torrent Server for operation. The product includes a one year warranty on parts, labor and travel for service personnel. A field service installation plan for the Personal Genome Machine System maximizes your productivity with installation of the Personal Genome Machine™ System by one of our certified field service engineers.

Features of the Personal Genome Machine™ Sequencing Platform Include:
• Scalable (1000x) semiconductor technology
• Natural biochemistry using inexpensive reagents
• Compatibility with all current library preparation methods
• Sequencing run a href="http://products.invitrogen.com/ivgn/product/4462917">更看更多times of about 2 hours
• A straightforward touchscreen user interface

The Personal Genome Machine™ advances Next-Generation sequencing to PostLight™ sequencing: the translation of chemical sequence information directly into digital form. PostLight™ technology means genetic sequencing is leveraged by the extreme scalability of semiconductor technology. Moore’s law is applied to genetic analysis.

Affordable Sequencing For Nearly Every Lab
Previous sequencing technologies have relied upon optical systems as bridges between the chemical and digital forms of sequence information. These systems have added tremendous costs to sequencers, relegating them to only the largest laboratories. By eliminating the need for the optical system, the Personal Genome Machine™ provides sequencing that is simpler, faster, more cost effective, and more scalable than any other technology available. With a small benchtop footprint and weight of 65 lbs (~30kg), low cost sequencing reagents, and a simple touchscreen user interface, the Personal Genome Machine™ brings next generation sequencing to nearly every lab.

Ion Power: PostLight™ Sequencing Produces Bits From Bases
The sequencing technology underlying the Personal Genome Machine (PGM™) exploits a well-characterized biochemical process: When a nucleotide is incorporated into a strand of DNA by a polymerase, a hydrogen ion (H+) is released as a byproduct. This hydrogen ion carries a charge which the PGM™ System’s ion sensor—essentially the world's smallest solid-state pH meter— can detect. As the sequencer floods the chip with one nucleotide after another, any nucleotide added to a DNA template will be detected as a voltage change, and the PGM™ System will call the base. If a nucleotide is not a match for a particular template, no voltage change will be detected and no base will be called for that template.

Massively Parallel Sequencing On Your Bench
A principal component of the Personal Genome Machine™ is the sequencing chip. This microprocessor chip incorporates an extremely dense array of >1 million micro-machined wells married to our proprietary ion sensor. Each well contains a different DNA template, allowing massively parallel sequencing. Chips can scale in density for any application, from small, targeted experiments to large genomes.

The Right Tool To Get Results Easily, Reliably, and Quickly
Because it detects nucleotide incorporation without the use of light, the Personal Genome Machine™ uses the simplest sequencing chemistry possible: natural nucleotides. There is no need for expensive and error-prone modified bases, enzymatic cascades, chemiluminescence, or fluorescence. Direct detection also means the incorporation of each nucleotide is recorded in seconds. As a result, you can do an entire run typically in about 2 hours. Library preparation methods currently used for next-generation sequencing can be used with the Personal Genome Machine™.

For Research Use Only. Not for use in diagnostics procedures

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