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Automated Cell Imaging System ImageXpress Pico

Introduction：
Digital microscopy with automated brightfield, fluorescence, and Digital Confocal imaging The ImageXpress® Pico Automated Cell Imaging System is more than a digital microscope, combining high-resolution imaging with powerful analysis. Whether running fluorescence imaging or brightfield assays, the automated imager features a comprehensive portfolio of preconfigured protocols for cell-based assays to shorten the learning curve, so you can start running experiments quickly. With features such as Digital Confocal* 2D on-the-fly deconvolution, Autofocus, Live Preview, multi-wavelength cell scoring, and optional IN Carta® Image Analysis Software workflow, the ImageXpress Pico offers you the ability to advance your discoveries in a small, affordable imager.   Get started quickly With the icon-driven, user-friendly CellReporterXpress® Image Acquisition and Analysis Software, your entire lab can streamline their digital microscopy. Start capturing and analyzing images with minimal training.   Do more than cell counting Expand your assays with over 25 preconfigured templates optimized for many cell-based experiments including apoptosis, mitochondrial evaluation, 3D cell models, live cell/timelapse, multiwavelength cell scoring, and neurite tracing.   Automate imaging affordably Alleviate the hassle of going to the core lab to run your samples. The system’s lab-friendly price allows researchers to afford the convenience of automated imaging and analysis on their lab bench. With options like Digital Confocal, environmental control and z-stack acquisition, the system can be ordered to fit your research.   Multiple imaging modes The ImageXpress Pico system offers objectives ranging from 4x to 63x and can operate in colorimetric, brightfield, fluorescence, or Digital Confocal 2D on-the-fly deconvolution imaging modes.   Preconfigured analysis protocols Over 25 preconfigured analysis protocols ranging from simple cell counting to sophisticated neurite tracing analysis. With features like the click-to-find tool, analysis parameters can be optimized by simply clicking on a few cells that match specific criteria.   Plate-to-individual cell view Data can be visualized at multiple levels from plate overview to individual cells. A wide variety of data visualization tools from the plate and cellular level empower users to learn as much as possible from their images and assays.   Z-stack acquisition Generate sharper images for more accurate segmentation using z-stack acquisition. Acquire a series of images at different focal points to capture more detail than with a single slice. Users can include all slices or select which slices to include in the final projection.   Quickly and easily identify regions of interest Live Preview simplifies identification of regions of interest, letting users pan around the sample and interactively adjust focus with a virtual joystick, saving time and effort.   Environmental control Multi-day, time lapse, and live cell assays can be run using the onboard environmental system with options for humidity, CO2, and O2 control. Optimized to prevent z-drift, the software also provides real-time monitoring of environmental state, ensuring optimal assay conditions.  

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Automated Imaging System ImageXpress Nano

Introduction：
Fluorescence imaging platform within reach of every lab The ImageXpress® Nano Automated Imaging System features a long life, solid state, light engine, and optics to reliably deliver the right assay sensitivity. Capture fine details of a variety of cellular and subcellular assays with this powerful and flexible fluorescent microscopy solution. The system includes MetaXpress® High-Content Image Acquisition and Analysis Software with tools for 2D and 3D imaging and time lapse analysis, as well as a range of needs from ease-of-use through to proprietary assay design.   Image label-free Brightfield imaging allows for rapid acquisition without the use of harmful fluorescent agents.   Streamline image analysis The modular toolbox in the MetaXpress® software allows for the quick setup of hundreds of routine assays. Choose from our optional selection of turnkey application modules for greater convenience.   Capture a diverse range of samples With 2x to 60x magnification, the system offers the flexibility to image whole-well (C. elegans, zebrafish), as well as sub-cellular details (vesicles, organelles).   Large field of view An entire well of a 384-well plate can be captured in a single image at 4x magnification for faster throughput.   Automated Stages Fully automated X, Y, and Z stages with resolution better than 25 nm.   Wide range of filters and objectives The system can be configured with different filters or objectives (2-60x) to meet research needs.   Five fluorescent channels The system can have up to 5 fluorescent filters installed at one time. The software allows up to 7 channels to be acquired at one time which enables multi-channel fluorescent and transmitted light imaging in one experiment.   High-speed autofocus Laser autofocus enables quick, consistent focusing across plates, slides and uneven surfaces.   Environmental control option Multi-day, time lapse and live cell assays can be run using the onboard environmental system with options for temprature, humidity, and CO2 control.  

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High-Content Imaging System ImageXpress Micro 4

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Widefield imaging for basic research through to high-content screening The ImageXpress® Micro 4 High-Content Imaging System is a high-throughput, widefield imager that can acquire images of whole organisms and cellular or intracellular events. It features proprietary fast frame rate technology, allowing for the capture of fast biological processes such as calcium oscillations in cardiomyocytes. It is highly configurable and adaptable to changing research needs. Available options include confocal, brightfield, phase contrast, liquid handing, and environmental control.   Support many cellular assays Image an incredible range of assays with various user-changeable filter cubes, 1-100x objectives, environmental control, fluidics option, and many sample formats including atypical plates for 3D assays.   Analyze images of more applications A selection of feature-rich turnkey application modules is available with MetaXpress® software. For the development of novel assays, we offer an optional custom analysis module.   Tailor the system to meet your needs The imager is a highly flexible solution, you can add or change many of the components as your research priorities change. Examples include enhance light engines and automation.   Multiple imaging modes The system offers fluorescence, widefield, colorimetric, phase contrast, and brightfield label-free imaging.   Upgradeable to confocal The system can be upgraded to include the proprietary AgileOptix™ technology for accurate 3D volumetric analyses.   Wide dynamic range Low and high intensity signal quantification in a single image with >3 log dynamic range intensity detection.   High speed image acquisition Using 4x magnification with a 1536-well plate, 225K wells per day can be acquired. Greater than a million wells per week can be imaged.   Optional environmental control Temperature, humidity, and CO2 control for multi-day live-cell imaging or fast kinetic studies are available.   Large magnification range Air and oil immersion objectives ranging from 1x to 100x are available for installation into the 4-position objective changer.    

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High-Content Imaging System ImageXpress Micro Confocal

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High-content confocal imaging solution with water objective options The ImageXpress® Micro Confocal system is a high-content solution that can switch between widefield and confocal imaging of fixed and live cells. It can capture high quality images of whole organisms, thick tissues, 2D and 3D models, and cellular or intracellular events. The spinning disk confocal and sCMOS camera enable imaging of fast and rare events like cardiac cell beating and stem cell differentiation. With MetaXpress software and flexible options like water immersion objectives to choose from, the system enables many confocal imaging applications from 3D assay development to screening.   Acquire higher quality images Capture excellent contrast, high resolution images with our proprietary AgileOptix™ spinning disk confocal technology, wide field of view, and bright light source.   Customize image acquisition and analysis Take ultimate control over acquisition and analysis parameters, which enables many applications from 3D structure analysis to target imaging of specific objects within an organism or cell populations. Run more applications with standard options like water immersion objectives, environmental control, or any of our high-performance customizations.   Analyze more data in less time MetaXpress® PowerCore™ software accelerates analysis speed in a high-throughput environment. The software distributes image processing jobs to a multi-CPU environment.   Wide dynamic range Quantify low and high intensity signals in a single image with >3 log dynamic range intensity detection.   Exclusive AgileOptix spinning disk confocal The technology provides increased sensitivity with specially designed optics, high-powered, solid state light engines, and sCMOS sensor. Swappable disc geometries provide flexibility between speed and resolution.   Wide field of view Wide field of view enables whole-well confocal imaging and eliminates missed targets.   Optional on-board robotic fluidics For assays that involve compound addition, well washing, and media exchange, optional on-board robotic fluidics are available.   Accurate 3D measurements MetaXpress 3D analysis module is optimized for confocal imaging, enabling 3D measurements of volume and distance.   Multiple imaging modes The system offers phase contrast and brightfield label-free imaging, fluorescence, widefield, colorimetric, and confocal imaging, as well as, water immersion imaging as a standard option.  

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High-Content Imaging System ImageXpress Confocol HT.ai

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Capture large 3D organoid and spheroid images with up to double the speed The ImageXpress® Confocal HT.ai High-Content Imaging System utilizes a seven-channel laser light source with eight imaging channels to enable highly multiplexed assays while maintaining high throughput by using shortened exposure times. Water immersion objectives improve image resolution and minimize aberrations so scientists can see deeper into thick samples. The powerful combination of MetaXpress® software and IN Carta® software simplifies workflows for advanced phenotypic classification and 3D image analysis with machine learning capabilities and an intuitive user interface.   Enable greater assay flexibility Eight imaging channels with laser excitation enable more assay flexibility, higher image brightness, and flexibility to use targeted imaging such as QuickID. Automated Water Immersion objectives offer greater numerical aperture and matched refractive index between the sample and the immersion media for enhanced resolution and decreased aberrations.   Increase throughput with higher quality images Higher excitation power provides increased signal, shorter exposure times, and faster acquisitions of 3D samples. Micro-lens enhanced spinning disk confocal provides a flat field of view for more accurate and reproducible image analysis. Shorter exposure times generates up to a two-fold boost in scan speed. FRET experiments using lasers for CFP and YFP expand research.   Accelerate analysis speeds IN Carta Image Analysis Software performs complex segmentation and classification. Phenoglyphs provides a robust trainable classification, and SINAP provides trainable segmentation for any image type. Accelerate analysis speeds by 40X with multi-threaded, parallel processing with MetaXpress® PowerCore Software. Reduces time from hours to minutes, eliminating 3D analysis as a bottleneck.   High-intensity laser light source Capture images faster with shorter exposure times. Multiplex your experiments with 7 lasers and 8 imaging channels.   Accurate 3D measurements Custom Module Editor 3D analysis is optimized for confocal imaging, enabling 3D measurements of volume and distance.   Wide field of view Wide field of view enables whole-well confocal imaging and eliminates missed targets. Next-generation dual microlens enhanced spinning disk technology provides a large, flat field of view for more accurate and reproducible analysis.   Exclusive AgileOptix™ spinning disk technology Provides increased sensitivity with specially designed optics, high-powered laser illumination, and sCMOS sensor. Swappable disk geometries provide flexibility between speed and resolution.   IN Carta Image Analysis Software Leverages machine learning to improve the accuracy and robustness of high-content image analysis, delivering data insights that other technologies miss. Reduces the complexity of image analysis with intuitive guided workflows in a modern user interface.   Multiple imaging modes The system offers phase contrast and brightfield label-free imaging, widefield and confocal fluorescent imaging with water immersion optics as a standard option.   Automated water immersion objective technology Offers greater image resolution and sensitivity with up to 4x increase in signal leading to lower exposure times.   Wide dynamic range Quantifies low and high intensity signals in a single image with >3 log dynamic range intensity detection.    

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